Dr. rer. hum. biol. Björn-Hergen Laabs

Institut für Medizinische Biometrie und Statistik
Universität zu Lübeck
Universitätsklinikum Schleswig-Holstein, Campus Lübeck
Ratzeburger Allee 160, V24
23562 Lübeck

fon: 0451-500 50620

b.laabs[at]uni-luebeck.de

Lebenslauf

1992 Geboren in Essen
2012 Abitur in Lübeck
2012 - 2015 Bachelorstudium "Mathematik in Medizin und Lebenswissenschaften" an der Universität zu Lübeck
2015 - 2017 Masterstudium "Mathematik in Medizin und Lebenswissenschaften" an der Universität zu Lübeck
2017 - 2022 Wissenschaftlicher Mitarbeiter und Doktorand am IMBS
seit 2022 Wissenschaftlicher Mitarbeiter und Postdoc am IMBS

Tätigkeiten in Wissenschaftlichen Fachgesellschaften

seit 2020 Stellvertretender Leiter der AG Nachwuchs der IBS-DR

Publikationen

Reduced penetrance in movement disorders

2019 Westenberger A, Reyes CJ, Saranza G, Dobricic V, Hanssen H, Domingo A, Laabs B-H, Schaake S, Pozojevic J, Rakovic A, Grütz K, Begemann K, Walter U, Dressler D, Bauer P, Rolfs A, Münchau A, Kaiser FJ, Ozelius LJ, Jamora RDG, Rosales RL, Diesta CCE, Lohmann K, König IR, Brüggemann N, Klein C. A hexanucleotide repeat modifies expressivity of X-linked dystonia-parkinsonism. Annals of Neurology 85(6):812-822
2020 Krause C, Schaake S, Grütz K, Sievert H, Reyes CJ, König IR, Laabs B-H, Jamora RDG, Rosales RL, Diesta CCE, Pozojevic J, Gemoll T, Westenberger A, Kaiser FJ, Klein C, Kirchner H. DNA Methylation as a Potential Molecular Mechanism in X-Linked Dystonia-Parkinsonism. Movement Disorders 35(12):2220-2229
2021 Laabs B-H, Klein C, Pozojevic J, Domingo A, Brüggemann N, Grütz K, Rosales RL, Jamora RDG, Saranza G, Diesta CCE, Wittig M, Schaake S, Mahlow MD, Quismundo J, Otto P, Acuna P, Go CL, Sharma N, Multhaupt-Buell TJ, Müller U, Hanssen H, Kilpert F, Franke A, Rolfs A, Bauer P, Dobricic V, Lohmann K, Ozelius LJ, Kaiser FJ, König IR, Westenberger A. Identifying genetic modifiers of age-associated penetrance in X-linked dystonia-parkinsonism. Nature Communications 12(1):3216
2021 Reyes CJ, Laabs B-H, Schaake S, Lüth T, Ardicoglu R, Rakovic A, Grütz K, Alvarez-Fischer D, Jamora RDG, Rosales RL, Weyers I, König IR, Brüggemann N, Klein C, Dobricic V, Westenberger A, Trinh J. Brain Regional Differences in Hexanucleotide Repeat Length in X-linked Dystonia-Parkinsonism Using Nanopore Sequencing. Neurology Genetics 7(4):1
2021 Balck A, Schaake S, Kuhnke NS, Domingo A, Madoev H, Margolesky J, Dobricic V, Alvarez-Fischer D, Laabs B-H, Kasten M, Luo W, Nicolas G, Marras C, Lohmann K, Klein C, Westenberger A. Genotype-Phenotype Relations in Primary Familial Brain Calcification: Systematic MDSGene Review. Movement Disorders 36(11):2468-2480
2021 Koch S, Laabs B-H, Kasten M, Vollstedt E-J, Becktepe JS, Brüggeman N, Franke A, Krämer U, Kuhlenbäumer G, Lieb W, Mollenhauer B, Neis M, Trenkwalder C, Schaeffer E, Usnich T, Wittig M, Klein C, König IR, Lohmann K, Krawczak M, Caliebe A. Validity and Prognostic Value of a Polygenic Risk Score for Parkinson’s Disease. Genes 12(12):1859
2022 Trinh J, Lüth T, Schaake S, Laabs B-H, Schlüter K, Laß J, Pozojevic J, Tse R, König IR, Jamora RDG, Rosales Rl, Brüggemann N, Saranza G, Diesta CCE, Kaiser FJ, Depienne C, Pearson CE, Westenberger A, Klein C. Mosaic divergent repeat interruptions in XDP influence repeat stability and disease onset. Brain awac160
2022 Steinhardt J, Hanßen H, Heldmann M, Sprenger A, Laabs B-H, Domingo A, Reyes CJ, Prasuhn J, Brand M, Rosales RL, Münte TF, Klein C, Westenberger A, Oropilla JQ, Diesta CCE, Brüggeman N. Prodromal X-Linked Dystonia-Parkinsonism is Characterized by a Subclinical Motor Phenotype. Movement Disorders 37(7):1474-1482
2022 Pozojevic J, Laabs B-H, Westenberger A. Factors influencing reduced penetrance and variable expressivity in X-linked dystonia-parkinsonism. Medizinische Genetik 34(2):97-102

Most representative trees

2022 Laabs B-H, Westenberger A, König IR. Identification of representative trees in random forests based on a new tree-based distance measure. bioRxiv

Mendelian Randomization Studies

2019 Libuda L, Laabs B-H, Ludwig C, Bühlmeier J, Antel J, Hinney A, Naaresh R, Föcker M, Hebebrand J, König IR, Peters T, Vitamin D and the Risk of Depression: A Causal Relationship? Findings from a Mendelian Randomization Study. Nutrients 11(5):1085
2020 Peters T, Nüllig L, Antel J, Naaresh R, Laabs B-H, Tegeler L, Amhaouach C, Libuda L, Hinney A, Hebebrand J, The Role of Genetic Variation of BMI, Body Composition, and Fat Distribution for Mental Traits and Disorders: A Look-Up and Mendelian Randomization Study. Frontiers in Genetics 11
2021 Libuda L, Naaresh R, Ludwig C, Laabs B-H, Antel J, Föcker M, Hebebrand J, Hinney A, Peters T, A mendelian randomization study on causal effects of 25(OH)vitamin D levels on attention deficit/hyperactivity disorder. European Journal of Nutrition 60(6):1-11